Imaging agents:

Indications for: ISOVUE-M 300

For intrathecal administration in adult neuroradiology inculding myelography (lumbar, thoracic, cervical, total columnar), and for contrast enhancement of computed tomographic (CECT) cisternography and ventriculography.

Adults and Children:

See full labeling regarding dosing based on procedure.

ISOVUE-M 300 Contraindications:

Concomitant corticosteroids. Repeat myelography in the event of technical failure. Significant local or systemic infections where bacteremia is likely.

ISOVUE-M 300 Warnings/Precautions:

Should be administered by professional trained in use of radiopaque agents in appropriate facilities with emergency treatment readily available. Increased intracranial pressure. Intracranial tumor. Abscess. Hematoma. History of convulsive disorder. Severe cardiovascular disease. Chronic alcoholism. Multiple sclerosis. Homozygous sickle cell disease. Multiple myeloma. Pheochromocytoma. Hyperthyroidism. Thyroid dysfunction (esp. children 0–3yrs); monitor. Diabetes. Patients with evidence of inadvertant intracranial entry of large or concentrated bolus of contrast medium: increased risk of seizures; consider prophylactic diazepam or barbiturate therapy. Direct intracisternal or ventricular administration for standard radiography: not recommended. Maintain elevation of head during procedure, on the stretcher, or in bed. Avoid excessive and active patient movement or straining. Maintain adequate hydration. Elderly. Pregnancy. Nursing mothers.

See Also:

ISOVUE-M 300 Classification:

Contrast media.

ISOVUE-M 300 Interactions:

Concomitant drugs that lower seizure threshold (eg, phenothiazines, MAOIs, tricyclics, CNS stimulants, analeptics, major tranquilizers, antipsychotics): not recommended; discontinue 48hrs and for at least 24hrs post-procedure. May reduce iodine-binding capacity of thyroid tissue for up to 2 weeks.

Adverse Reactions:

Headache, GI upset, back pain, leg pain, neck pain, hypotension, others.

How Supplied:

ISOVUE-M 200: Single dose vials (10mL, 20mL)—10; ISOVUE-M 300: Single dose vials (15mL)—10