Anemias:
Indications for: Leucovorin
Megalobastic anemia due to folic acid deficiency when oral therapy is not feasible.
Adult Dosage:
Up to 1mg daily.
Children Dosage:
See literature.
Leucovorin Contraindications:
Pernicious anemia and other megaloblastic anemias due to Vit. B12 deficiency.
Leucovorin Warnings/Precautions:
Do not administer intrathecally. CNS metastases. Monitor CBCs with differential, platelets, electrolytes, liver function tests prior to each treatment, then periodically. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.
Leucovorin Classification:
Folic acid derivative.
Leucovorin Interactions:
Potentiates toxicity of 5-fluorouracil; use lower 5-fluorouracil dose. May antagonize phenobarbital, phenytoin, and primidone. Caution with trimethoprim-sulfamethoxazole.
Adverse Reactions:
Leukopenia, thrombocytopenia, infection, GI upset, stomatitis, constipation, lethargy, malaise, fatigue, alopecia, dermatitis, anorexia; seizures, syncope.
How Supplied:
Single-use vials—1
Colorectal and other GI cancers:
Indications for: Leucovorin
Palliative treatment of advanced colorectal cancer in combination with 5-fluorouracil.
Adult Dosage:
Max IV infusion rate: 160mg/min. 200mg/m2 by slow IV inj over a minimum of 3 minutes, followed by 5-fluorouracil (370mg/m2); or 20mg/m2 IV followed by 5-fluorouracil (425mg/m2); both regimens: daily for 5 days, may be repeated at 4-week intervals for 2 courses and then repeated at 4–5 week intervals (if completely recovered from toxic effects of previous course).
Children Dosage:
See literature.
Leucovorin Contraindications:
Pernicious anemia and other megaloblastic anemias due to Vit. B12 deficiency.
Leucovorin Warnings/Precautions:
Do not administer intrathecally. CNS metastases. Monitor CBCs with differential, platelets, electrolytes, liver function tests prior to each treatment, then periodically. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.
Leucovorin Classification:
Folic acid derivative.
Leucovorin Interactions:
Potentiates toxicity of 5-fluorouracil; use lower 5-fluorouracil dose. May antagonize phenobarbital, phenytoin, and primidone. Caution with trimethoprim-sulfamethoxazole.
Adverse Reactions:
Leukopenia, thrombocytopenia, infection, GI upset, stomatitis, constipation, lethargy, malaise, fatigue, alopecia, dermatitis, anorexia; seizures, syncope.
How Supplied:
Single-use vials—1
Cytoprotective and supportive care agents:
Indications for: Leucovorin
Rescue treatment after high-dose methotrexate therapy in osteosarcoma.
Adult Dosage:
Max IV infusion rate: 160mg/min. Based on methotrexate dose. Normal methotrexate elimination: 15mg IM or IV every 6 hours for 10 doses starting 24 hours after the beginning of the methotrexate infusion. Delayed late or delayed early methotrexate elimination, and/or evidence of acute renal injury, impaired methotrexate elimination or inadvertent overdosage: see literature.
Children Dosage:
See literature.
Leucovorin Contraindications:
Pernicious anemia and other megaloblastic anemias due to Vit. B12 deficiency.
Leucovorin Warnings/Precautions:
Do not administer intrathecally. Monitor serum methotrexate concentration. CNS metastases. Monitor CBCs with differential, platelets, electrolytes, liver function tests prior to each treatment, then periodically. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.
Leucovorin Classification:
Folic acid derivative.
Leucovorin Interactions:
Potentiates toxicity of 5-fluorouracil; use lower 5-fluorouracil dose. May antagonize phenobarbital, phenytoin, and primidone. Caution with trimethoprim-sulfamethoxazole.
Adverse Reactions:
Leukopenia, thrombocytopenia, infection, GI upset, stomatitis, constipation, lethargy, malaise, fatigue, alopecia, dermatitis, anorexia; seizures, syncope.
How Supplied:
Single-use vials—1
