Anxiety/OCD:
Indications for: LEXAPRO
Generalized anxiety disorder.
Adult Dosage:
Initially 10mg once daily; may increase to max 20mg once daily at an interval of no less than 1 week. Elderly or hepatic impairment: 10mg once daily.
Children Dosage:
<7yrs: not established. Initially 10mg once daily; may increase to max 20mg once daily at an interval of no less than 2 weeks. Hepatic impairment: 10mg once daily.
LEXAPRO Contraindications:
During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. Concomitant pimozide, linezolid, IV methylene blue.
Boxed Warning:
Suicidality and antidepressant drugs.
LEXAPRO Warnings/Precautions:
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic impairment: see Adult and Children Dosage. Renal impairment (CrCl <20mL/min): not studied. Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. Hyponatremia (esp. elderly). Sexual dysfunction. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (during 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.
See Also:
LEXAPRO Classification:
SSRI.
LEXAPRO Interactions:
See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.
Adverse Reactions:
Insomnia, ejaculation disorder, nausea, increased sweating, fatigue, somnolence, decreased libido, anorgasmia.
Drug Elimination:
Half-life: ~27–32 hours.
Oral clearance: 600 mL/min.
How Supplied:
Tabs—100; Soln—contact supplier
Mood disorders:
Indications for: LEXAPRO
Major depressive disorder (MDD).
Adult Dosage:
Initially 10mg once daily; may increase to max 20mg once daily at an interval of no less than 1 week. Elderly or hepatic impairment: 10mg once daily.
Children Dosage:
<12yrs: not established. 12–17yrs: initially 10mg once daily; may increase to 20mg once daily after 3 weeks.
LEXAPRO Contraindications:
During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. Concomitant pimozide, linezolid, IV methylene blue.
Boxed Warning:
Suicidality and antidepressant drugs.
LEXAPRO Warnings/Precautions:
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic impairment: see Adult and Children Dosage. Renal impairment (CrCl <20mL/min): not studied. Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. Hyponatremia (esp. elderly). Sexual dysfunction. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (during 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.
See Also:
LEXAPRO Classification:
SSRI.
LEXAPRO Interactions:
See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.
Adverse Reactions:
Insomnia, ejaculation disorder, nausea, increased sweating, fatigue, somnolence, decreased libido, anorgasmia.
Drug Elimination:
Half-life: ~27–32 hours.
Oral clearance: 600 mL/min.
How Supplied:
Tabs—100; Soln—contact supplier
