Select therapeutic use:

Colorectal disorders:

Indications for: LINZESS

Irritable bowel syndrome with constipation (IBS-C).

Adult Dosage:

Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. 290mcg once daily.

Children Dosage:

<2yrs: contraindicated. 2–<18yrs: not established.

LINZESS Contraindications:

Children <2yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients <2yrs of age.

LINZESS Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

LINZESS Classification:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Metabolism:

GI.

Drug Elimination:

Fecal.

Generic Drug Availability:

NO

How Supplied:

Caps—30

Constipation and bowel cleansers:

Indications for: LINZESS

Chronic idiopathic constipation (CIC) in adults. Functional constipation (FC) in pediatric patients.

 

Adult Dosage:

FC (≥18yrs): not established. Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. CIC (≥18yrs): 145mcg once daily. A dosage of 72mcg once daily may be used based on individual presentation or tolerability.

Children Dosage:

<2yrs: contraindicated. CIC (<18yrs): not established. FC (<6yrs): not established. Swallow whole. Take on empty stomach, at least 30mins before first meal of the day. May open caps and mix contents in applesauce or with water if unable to swallow; or, may give with water via NG or gastrostomy tube. FC (6–17yrs): 72mcg once daily.

LINZESS Contraindications:

Children <2yrs old. Known or suspected mechanical GI obstruction.

Boxed Warning:

Risk of serious dehydration in pediatric patients <2yrs of age.

LINZESS Warnings/Precautions:

Consider dose suspension and rehydration if severe diarrhea occurs. Pregnancy. Nursing mothers.

LINZESS Classification:

Guanylate cyclase-C agonist.

Adverse Reactions:

Diarrhea, abdominal pain, flatulence, abdominal distention.

Metabolism:

  • Linaclotide is metabolized within the gastrointestinal tract to its principal, active metabolite by loss of the terminal tyrosine moiety. Both linaclotide and the metabolite are proteolytically degraded within the intestinal lumen to smaller peptides and naturally occurring amino acids.

Drug Elimination:

Fecal.

Generic Drug Availability:

NO

How Supplied:

Caps—30