Indications for: MACROBID
For the treatment of acute uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus.
Limitations of Use:
Not indicated for the treatment of pyelonephritis or perinephric abscesses.
In controlled clinical trials comparing Macrobid 100mg every 12 hours and Macrodantin 50mg every 6 hours for the treatment of acute uncomplicated UTIs, approximately 75% microbiologic eradication of susceptible pathogens was observed in each treatment group.
Take with meals. 100mg every 12hrs for 7 days.
Anuria, oliguria, CrCl <60mL/min. Neonates <1 month of age. Labor & delivery. Pregnancy at term. History of cholestatic jaundice/hepatic dysfunction associated with nitrofurantoin.
Not for treating pyelonephritis or perinephric abscesses. Discontinue if pulmonary reactions, hepatic disorders, or hemolysis occurs. Renal insufficiency; monitor (esp. in elderly). G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Monitor renal function and pulmonary condition in long-term use. Debilitated. Pregnancy (Cat.B). Nursing mothers: not recommended.
Reduced absorption by magnesium trisilicate. Uricosurics (eg, probenecid, sulfinpyrazone) may inhibit tubular secretion. May cause false (+) glucose test with Benedict's or Fehling's solution.
Nausea, headache, flatulence, dizziness, alopecia; C. diff-associated diarrhea, pulmonary disorders, hepatic damage, hemolytic anemia, peripheral neuropathy (may be irreversible), anaphylaxis, blood dyscrasias; rare: exfoliative dermatitis, Stevens-Johnson syndrome, aplastic anemia.
Renal. Half-life: 0.72–0.78 hours.