Edema:
Indications for: MAXZIDE
Edema.
Adult Dosage:
Initially one Maxzide-25mg tab/day. Usual dosage: 1–2 Maxzide-25mg tabs or one Maxzide tab once daily. As a substitute for triamterene 50–100mg/day and hydrochlorothiazide 25–50mg/day in less bioavailable form, give one Maxzide-25mg tab/day.
Children Dosage:
Not established.
MAXZIDE Contraindications:
Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.
Boxed Warning:
Risk of hyperkalemia.
MAXZIDE Warnings/Precautions:
Diabetes. Acidosis predisposition. Electrolyte imbalance. Excessive diuresis. History of renal stones. Gout. Asthma. SLE. Surgery. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Elderly. Severely ill. Pregnancy. Nursing mothers: not recommended.
See Also:
MAXZIDE Classification:
Diuretic (K+ sparing) + (thiazide).
MAXZIDE Interactions:
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Hyperkalemia more likely with ACE inhibitors. NSAIDs may cause renal failure. Hypokalemia with corticosteroids, ACTH, amphotericin B. Hypotension with CNS depressants. Potentiates other antihypertensives, nondepolarizing muscle relaxants. Antagonized by NSAIDs. Hyponatremia with sulfonylureas. Antagonizes folic acid. May block epinephrine. May interfere with parathyroid tests.
Adverse Reactions:
Drowsiness, insomnia, muscle cramps, weakness, headache, GI disturbances, dizziness, orthostatic hypotension, hyperuricemia, impotence, renal stones, tachycardia, dyspnea, dry mouth, depression, anxiety, urine discoloration, elevated liver enzymes; HCTZ: increased risk for non-melanoma skin cancer.
How Supplied:
Tabs—100
Hypertension:
Indications for: MAXZIDE
Hypertension when normokalemia is essential.
Adult Dosage:
1 tab daily.
Children Dosage:
Not established.
MAXZIDE Contraindications:
Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.
Boxed Warning:
Risk of hyperkalemia.
MAXZIDE Warnings/Precautions:
Diabetes. Acidosis predisposition. Electrolyte imbalance. Excessive diuresis. History of renal stones. Gout. Asthma. SLE. Surgery. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Elderly. Severely ill. Pregnancy. Nursing mothers: not recommended.
See Also:
MAXZIDE Classification:
Diuretic (K+ sparing) + (thiazide).
MAXZIDE Interactions:
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Hyperkalemia more likely with ACE inhibitors. NSAIDs may cause renal failure. Hypokalemia with corticosteroids, ACTH, amphotericin B. Hypotension with CNS depressants. Potentiates other antihypertensives, nondepolarizing muscle relaxants. Antagonized by NSAIDs. Hyponatremia with sulfonylureas. Antagonizes folic acid. May block epinephrine. May interfere with parathyroid tests.
Adverse Reactions:
Drowsiness, insomnia, muscle cramps, weakness, headache, GI disturbances, dizziness, orthostatic hypotension, hyperuricemia, impotence, renal stones, tachycardia, dyspnea, dry mouth, depression, anxiety, urine discoloration, elevated liver enzymes; HCTZ: increased risk for non-melanoma skin cancer.
How Supplied:
Tabs—100
