Bone disorders:

Indications for: MIACALCIN INJECTION

Paget's disease of bone. Hypercalcemia. Postmenopausal osteoporosis in women >5yrs postmenopausal.

Adult Dosage:

Give by IM inj across multiple sites if total dose >2mL. Paget's: 100 IU SC or IM daily. Hypercalcemia: initially 4 IU/kg SC or IM every 12hrs, may increase after 1–2 days to 8 IU/kg every 12hrs, and then after 2 more days to max 8 IU/kg every 6hrs. Postmenopausal osteoporosis: 100 IU SC or IM daily.

Children Dosage:

Not established.

MIACALCIN INJECTION Warnings/Precautions:

Correct hypocalcemia and other mineral metabolism disorders before initiating; monitor serum calcium and hypocalcemia symptoms during therapy. Increased risk of malignancies. Consider periodic exams of urine sediment; serum alkaline phosphatase and urinary hydroxyproline in Paget's. Postmenopausal osteoporosis: supplement diet with calcium 1g/day and Vit.D 400 IU/day. Re-evaluate periodically. Pregnancy. Nursing mothers.

MIACALCIN INJECTION Classification:

Hormone.

MIACALCIN INJECTION Interactions:

May antagonize lithium (consider lithium dose adjustment).

Adverse Reactions:

Nausea, vomiting, local inflammation, flushing, rash; hypersensitivity reactions, anaphylaxis, hypocalcemia, antibody formation.

How Supplied:

Multi-dose vials (2mL)—1