Gout:
Indications for: MITIGARE
Prophylaxis of gout flares.
Limitations of Use:
Not studied for acute treatment of gout flares during prophylaxis. Not for treating pain from other causes.
Adult Dosage:
0.6mg once or twice daily; max 1.2mg/day.
Children Dosage:
Not established.
MITIGARE Contraindications:
Renal or hepatic impairment with concomitant CYP3A4 and P-gp dual inhibitors (life-threatening toxicity possible). Concurrent renal and hepatic impairment.
MITIGARE Warnings/Precautions:
Monitor for toxicity; if present, consider temporary interruption or discontinuation. Renal or hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.
MITIGARE Classification:
Antiinflammatory.
MITIGARE Interactions:
See Contraindications. Avoid concomitant CYP3A4 inhibitors (eg, clarithromycin, ketoconazole, grapefruit juice, erythromycin, verapamil) and/or P-gp inhibitors (eg, clarithromycin, ketoconazole, cyclosporine); if unavoidable, reduce daily dose or frequency, and monitor for colchicine toxicity. Concomitant statins, fibrates may potentiate myopathy and rhabdomyolysis.
Adverse Reactions:
Diarrhea, nausea, vomiting, abdominal pain; blood dyscrasias, neuromuscular toxicity, rhabdomyolysis, overdosage (may be fatal).
How Supplied:
Caps—100, 1000
