Indications for MONOKET:
Prophylaxis and treatment of angina. Not for acute attacks.
20mg upon awakening then 20mg 7 hrs later. Small patients: may start with 5mg per dose for 1 day, then increase to 10mg by 2nd or 3rd day (scheduled as above).
Concomitant PDE-5 inhibitors (eg, sildenafil, tadalafil, vardenafil), riociguat.
Acute MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Monitor for tolerance. Pregnancy (Cat.B). Nursing mothers.
See Contraindications. Severe hypotension, syncope, or myocardial ischemia with PDE-5 inhibitors; or hypotension with riociguat. Orthostatic hypotension with alcohol, other vasodilators, calcium channel blockers.
Headache, dizziness, orthostatic hypotension, GI upset, upper respiratory infection.