Constipation and bowel cleansers:
Indications for: MOVIPREP
Bowel cleansing before colonoscopy.
Adult Dosage:
No solid food from start of prep. For both regimens start the evening before colonoscopy. Split-dose regimen: drink 240mL every 15mins over 1hr until 1L consumed, follow with 480mL of clear liquids; in the AM (start ≥3.5hrs before colonoscopy), drink 2nd liter over 1hr, then drink 480mL of clear liquids at least 2hrs before colonoscopy; or, Evening-only regimen: start at least 3.5hrs before bedtime; drink 240mL every 15mins over 1hr until 1L consumed, then drink 2nd liter 1.5hrs later over 1hr; in addition, drink 1L of clear liquids.
Children Dosage:
<18yrs: not established.
MOVIPREP Contraindications:
GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic colitis or megacolon.
MOVIPREP Warnings/Precautions:
Correct fluid/electrolyte abnormalities prior to initiation. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, cardiomyopathy, or electrolyte imbalance: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History or risk of seizures. Renal impairment: perform baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex or swallowing abnormalities: risk for regurgitation or aspiration. G6PD deficiency. Phenylketonuria. Maintain adequate hydration. Pregnancy. Nursing mothers.
MOVIPREP Classification:
Osmotic laxative.
MOVIPREP Interactions:
Avoid concomitant with starch-based thickeners. Caution with drugs that increase risk of fluid/electrolyte abnormalities, renal impairment, seizures, arrhythmias, or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Concomitant stimulant laxatives: not recommended; may increase risk of mucosal ulceration, ischemic colitis. Oral drugs administered within 1hr of start of MoviPrep may not be absorbed.
Adverse Reactions:
Malaise, nausea, vomiting, abdominal distension and pain (give slowly or discontinue if occurs), anal discomfort, thirst, sleep disorder, rigors, hunger, dizziness; hypersensitivity reactions; rare: arrhythmias, seizures.
Generic Drug Availability:
NO
How Supplied:
Carton—1 (disposable container w. 4 pouches)
