Muscle spasms:
Indications for: MYOBLOC
Cervical dystonia, to reduce severity of abnormal head position and neck pain. Chronic sialorrhea.
Adult Dosage:
Should be administered and managed by experienced physicians. Individualize. Cervical dystonia (treatment-experienced): initially 2500–5000 Units divided among affected muscles; (treatment-naïve): use lower initial dose. Sialorrhea: 1500–3500 Units divided among the parotid (500–1500 Units/gland) and submandibular (250 Units/gland) glands. May repeat treatments no sooner than every 12 weeks. Both: adjust subsequent doses based on response.
Children Dosage:
Not established.
MYOBLOC Contraindications:
Infection at proposed inj site.
Boxed Warning:
Distant spread of toxin effect.
MYOBLOC Warnings/Precautions:
Not interchangeable with other botulinum toxin products. Risk of distant spread of toxin effect (esp. in children treated for spasticity); see full labeling. Pre-existing dysphagia or breathing difficulties. Neuromuscular disorders (eg, myasthenia gravis, ALS, Lambert-Eaton syndrome); monitor closely. Compromised respiratory function; monitor. Contains human albumin; monitor for possible viral disease or Creutzfeldt-Jakob disease transmission. Pregnancy. Nursing mothers.
MYOBLOC Classification:
Neuromuscular blocker.
MYOBLOC Interactions:
May be potentiated by aminoglycosides or other agents interfering with neuromuscular transmission (eg, curare-like compounds). May potentiate anticholinergic effects with concomitant anticholinergic drugs. Concomitant other botulinum toxin products or muscle relaxants may potentiate neuromuscular weakness.
Adverse Reactions:
Dry mouth, dysphagia (may be severe), inj site pain, headache; hypersensitivity reactions (discontinue if occur), possible antibody formation.
Generic Drug Availability:
NO
How Supplied:
Single-use vial—1
