• Poisoning/overdose


Indications for NARCAN NASAL SPRAY:

Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.

Adults and Children:

Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3 mins in alternate nostrils if unresponsive or relapses into respiratory depression. Seek immediate emergency medical assistance after the first dose.


Not a substitute for emergency medical care. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.

Pharmacologic Class:

Opioid antagonist.


Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.

Adverse Reactions:

Increased BP, musculoskeletal pain, headache, nasal effects (eg, dryness, edema, congestion, inflammation); opioid withdrawal.

Generic Availability:


How Supplied:

Single-dose nasal spray—2