Indications for: Nifedipine Ext-Rel


Adult Dosage:

Swallow whole. Initially 30 or 60mg once daily, titrate over 7–14 days; max 120mg/day.

Children Dosage:

Not established.

Nifedipine Ext-Rel Warnings/Precautions:

Aortic stenosis. Severe obstructive coronary artery disease. Heart failure. GI narrowing/ulcers (tabs). Monitor blood pressure initially and during titration. Avoid abrupt cessation. Pregnancy. Nursing mothers.

Nifedipine Ext-Rel Classification:

Calcium channel blocker (CCB) (dihydropyridine).

Nifedipine Ext-Rel Interactions:

Severe hypotension, angina, and CHF possible with beta-blockers. Avoid concomitant phenytoin or CYP3A4 inducers; consider alternative antihypertensive therapy. Avoid concomitant grapefruit or grapefruit juice. Potentiated by CYP3A inhibitors (eg, fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir), or cimetidine; consider initiating nifedipine at lowest dose. Potentiates digoxin (monitor). Hypotension possible with fentanyl. GI obstruction possible with H2-blockers, opiates, NSAIDs, laxatives, anticholinergics, levothyroxine, neuromuscular blockers. Monitor oral anticoagulants, quinidine. Taper beta-blockers before initiating nifedipine.

Adverse Reactions:

Edema, headache, flushing, dizziness, fatigue, constipation, muscle cramps; rare: increased angina, acute MI, elevated enzymes.


Formerly known under the brand name Adalat CC.

How Supplied:

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