Prostate and other male cancers:
Indications for: NILANDRON
Metastatic prostate cancer (Stage D2), as an adjunct to surgical castration.
Adult Dosage:
300mg once daily for 30 days then 150mg once daily, starting day of or day after surgical castration.
Children Dosage:
Not applicable.
NILANDRON Contraindications:
Severe hepatic impairment or respiratory insufficiency.
Boxed Warning:
Interstitial pneumonitis.
NILANDRON Warnings/Precautions:
Obtain baseline liver and pulmonary function tests, routine chest X-ray. Monitor for interstitial pneumonitis; discontinue if symptoms occur. Monitor liver function for first 4 months then periodically; discontinue if ALT > 2xULN or jaundice occurs. May discolor urine or sclera. Pregnancy (not for use in women). Nursing mothers.
NILANDRON Classification:
Antiandrogen.
NILANDRON Interactions:
Monitor drugs metabolized by CYP450 (eg, Vit. K antagonists, theophylline, phenytoin); may need to adjust dose. May cause alcohol intolerance.
Adverse Reactions:
Hot flushes, impaired night vision, GI upset, increased liver enzymes, constipation, dizziness, abnormal vision, hypertension, hepatitis, interstitial pneumonitis.
How Supplied:
Tabs—30
