Prostate and other male cancers:

Indications for NUBEQA:

Treatment of non-metastatic, castration-resistant prostate cancer.

Adult:

Swallow whole. Take with food. 600mg twice daily. Give concurrent GnRH analog or patient should have had bilateral orchiectomy. Severe renal impairment (eGFR 15–29mL/min/1.73m2) not on hemodialysis: 300mg twice daily. Moderate hepatic impairment (Child-Pugh Class B): 300mg twice daily. Dose modification: see full labeling.

Children:

Not established.

Warnings/Precautions:

Embryo-fetal toxicity. Advise males (w. female partners of reproductive potential) to use effective contraception during and for 1 week after last dose.

Pharmacologic Class:

Androgen receptor inhibitor.

Interactions:

Antagonized by combined P-gp and strong or moderate CYP3A4 inducers; avoid. Potentiated by combined P-gp and strong CYP3A4 inhibitors; monitor and adjust dose. Avoid concomitant use with BCRP substrates; if unavoidable, monitor and consider dose reduction of the substrate drug.

Adverse Reactions:

Fatigue, pain in extremity, rash; ischemic heart disease, heart failure, lab abnormalities (increased AST and bilirubin, decreased neutrophil count).

Generic Availability:

NO

How Supplied:

Tabs—120

Pricing for NUBEQA

300mg tablet (Qty: 60)
Appx. price $5900
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