Migraine and headache:
Indications for NURTEC ODT:
Acute treatment of migraine with or without aura.
Limitations of Use:
Not for preventive treatment of migraine.
75mg once (max daily dose). The safety of treating more than 15 migraines in a 30-day period has not been established.
Discontinue if hypersensitivity reaction occurs; treat appropriately. Severe hepatic impairment (Child-Pugh C) or ESRD (CrCl <15mL/min): avoid. Dialysis: not studied. Pregnancy. Nursing mothers.
Calcitonin gene-related peptide (CGRP) receptor antagonist.
Potentiated by strong CYP3A4 inhibitors (eg, itraconazole); avoid concomitant use. May be potentiated by moderate CYP3A4, P-gp, or BCRP inhibitors. Avoid another dose of Nurtec ODT within 48hrs when used with moderate CYP3A4 inhibitors. May be antagonized by moderate or strong CYP3A inducers (eg, rifampin); avoid concomitant use.
Nausea; delayed serious hypersensitivity.
Fecal, renal. Half-life: ~11 hours.