Bleeding disorders:
Indications for: RHOPHYLAC
Raising platelet counts in Rho (D) positive non-splenectomized patients with chronic immune thrombocytopenic purpura (ITP).
Adult Dosage:
See full labeling. 250 IU (50mcg) per kg by IV only at rate of 2mL per 15–60 secs.
Children Dosage:
Not recommended.
RHOPHYLAC Contraindications:
Rho (D) positive patients. IgA deficiency. Newborn infant of a mother that received Rhophylac postpartum.
Boxed Warning:
Intravascular hemolysis in immune thrombocytopenic purpura (see full labeling).
RHOPHYLAC Warnings/Precautions:
Monitor patients 20 mins after administration. Have epinephrine available. Discontinue if hypersensitivity reactions occur. Risk of infectious agent transmission (eg, viruses, Creutzfeldt-Jakob disease agent). Pre-existing anemia. Pregnancy (Cat.C).
RHOPHYLAC Interactions:
Do not give live vaccines within 3 months.
Adverse Reactions:
Local or infusion reactions, fever, chills, headache; see full labeling.
How Supplied:
Single-dose prefilled syringes—1, 10
Immune-mediated blood disorders:
Indications for: RHOPHYLAC
Suppression of Rh isoimmunization in non-sensitized Rho (D) negative women during pregnancy and in appropriate obstetrical conditions, unless the fetus or father is known to be Rho (D) negative. Suppression of Rh isoimmunization in Rho (D) negative individuals transfused with Rho (D) positive blood products.
Adult Dosage:
See full labeling. Pregnancy (28–30 weeks gestation), postpartum prevention (within 72hrs), obstetric complications, invasive procedures during pregnancy: 1500 IU (300mcg). Incompatible transfusions (within 72hrs): 100 IU (20mcg) per 2mL transfused blood or per 1mL erythrocyte concentrate.
Children Dosage:
Not recommended.
RHOPHYLAC Contraindications:
Rho (D) positive patients. IgA deficiency. Newborn infant of a mother that received Rhophylac postpartum.
RHOPHYLAC Warnings/Precautions:
Monitor patients 20 mins after administration. Have epinephrine available. Discontinue if hypersensitivity reactions occur. Risk of infectious agent transmission (eg, viruses, Creutzfeldt-Jakob disease agent). Pre-existing anemia. Pregnancy (Cat.C).
RHOPHYLAC Interactions:
Do not give live vaccines within 3 months.
Adverse Reactions:
Local or infusion reactions, fever, chills, headache; see full labeling.
How Supplied:
Single-dose prefilled syringes—1, 10
