Indications for TAPAZOLE:
Initially 15–60mg daily in 3 divided doses, depending on severity of disease. Maintenance: 5–15mg daily.
Initially 0.4mg/kg daily in 3 divided doses. Maintenance: ½ initial dose.
Discontinue if agranulocytosis, aplastic anemia, exfoliate dermatitis, hepatitis, or elevated liver transaminases (3xULN) occurs. Monitor prothrombin time, WBC, bone marrow function. Pregnancy (Cat.D).
Rash, GI disturbances, arthralgia, paresthesia, hair and taste loss, agranulocytosis, blood dyscrasias, aplastic anemia, hepatic dysfunction, drug fever, lupus-like syndrome, insulin autoimmune syndrome, periarteritis; nephritis (rare).