Miscellaneous ocular agents:
Indications for TEPEZZA:
Thyroid eye disease.
Give 1st two infusions by IV infusion over 90mins; if tolerated, may reduce subsequent infusions to 60mins. Initially 10mg/kg followed by 20mg/kg every 3 weeks for 7 additional infusions.
Exacerbation of preexisting inflammatory bowel disease; if suspected, consider discontinuation. Monitor for hyperglycemia. Preexisting diabetes. Advise females of reproductive potential to use effective contraception prior to initiation, during and for 6 months after the last dose. Pregnancy: not recommended. Nursing mothers.
Human insulin-like growth factor-1 receptor inhibitor (IGF-1R).
Muscle spasm, nausea, alopecia, diarrhea, fatigue, hyperglycemia, hearing impairment, dry skin, dysgeusia, headache; infusion-related reactions.