Digestive and biliary disorders:

Indications for: URSO

Primary biliary cirrhosis.

Adult Dosage:

Take with food. 13–15mg/kg per day in 2–4 divided doses.

Children Dosage:

Not established.

URSO Contraindications:

Complete biliary obstruction.

URSO Warnings/Precautions:

Variceal bleeding, hepatic encephalopathy, ascites, and/or need for an urgent liver transplant: give appropriate specific treatment. Monitor liver function and bilirubin monthly for 3 months after starting therapy, then every 6 months thereafter; consider discontinuing if levels increase significantly with history of stable liver function. Monitor and maintain bile flow. Pregnancy (Cat.B). Nursing mothers.

See Also:

URSO Classification:

Bile acid.

URSO Interactions:

Reduced absorption with bile acid sequestrants (eg, cholestyramine, colestipol), and aluminum-containing antacids. Estrogens, oral contraceptives, clofibrate, other lipid-lowering drugs may reduce effectiveness of ursodiol by increasing hepatic cholesterol secretion.

Adverse Reactions:

Abdominal discomfort or pain, alopecia, diarrhea, nausea, pruritus, rash, leukopenia, elevated creatinine or blood glucose, thrombocytopenia.

How Supplied:

Tabs—100; Forte—100