Colorectal disorders:
Indications for: XIFAXAN 550mg
Irritable bowel syndrome with diarrhea (IBS-D).
Adult Dosage:
≥18yrs: 550mg three times daily for 14 days. Recurrent episodes: can retreat up to two times with the same dosage regimen.
Children Dosage:
<18yrs: not established.
XIFAXAN 550mg Warnings/Precautions:
Not studied in patients with MELD scores >25 (only 8.6% of patients in the controlled trial had MELD >19). Severe hepatic impairment (Child-Pugh C). Elderly. Pregnancy. Nursing mothers.
XIFAXAN 550mg Classification:
Rifamycin.
XIFAXAN 550mg Interactions:
Potentiated by P-gp inhibitors (eg, cyclosporine); caution. Monitor INR and PT with warfarin; dose adjustment may be needed.
Adverse Reactions:
Peripheral edema, nausea, dizziness, fatigue, ascites, increased ALT.
How Supplied:
Tabs—60
Hepatic encephalopathy:
Indications for: XIFAXAN 550mg
Reduction in risk of overt hepatic encephalopathy recurrence.
Adult Dosage:
≥18yrs: 550mg twice daily.
Children Dosage:
<18yrs: not established.
XIFAXAN 550mg Warnings/Precautions:
Not studied in patients with MELD scores >25 (only 8.6% of patients in the controlled trial had MELD >19). Severe hepatic impairment (Child-Pugh C). Elderly. Pregnancy. Nursing mothers.
XIFAXAN 550mg Classification:
Rifamycin.
XIFAXAN 550mg Interactions:
Potentiated by P-gp inhibitors (eg, cyclosporine); caution. Monitor INR and PT with warfarin; dose adjustment may be needed.
Adverse Reactions:
Peripheral edema, nausea, dizziness, fatigue, ascites, increased ALT.
How Supplied:
Tabs—60
