Seizure disorders:
Indications for: ZARONTIN
Absence seizures.
Adult Dosage:
Initially: 500mg daily. Increase every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses.
Children Dosage:
<3yrs: not established. 3–6yrs: initially 250mg daily. >6yrs: initially 500mg daily. Increase both every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses. Usual maintenance: 20mg/kg/day in divided doses.
ZARONTIN Warnings/Precautions:
Impaired hepatic or renal function. May precipitate tonic-clonic seizures. Discontinue at 1st sign of rash; consider alternative therapy if signs/symptoms of Stevens-Johnson syndrome occurs. Evaluate immediately if signs/symptoms of DRESS/multi-organ hypersensitivity develop; discontinue if no alternative etiology. Monitor for depression, suicidal ideation, unusual changes in mood/behavior. Monitor CBCs, kidney and liver function periodically. Change dose gradually. Pregnancy. Nursing mothers: not recommended.
See Also:
ZARONTIN Classification:
Succinimide.
ZARONTIN Interactions:
Monitor phenytoin, phenobarbital, valproic acid, other AEDs.
Adverse Reactions:
Blood dyscrasias, drowsiness, ataxia, dizziness, headache, GI upset, CNS and psychiatric effects, rash (may be fatal), SLE, DRESS, gingival hyperplasia.
Drug Elimination:
Renal.
Generic Drug Availability:
Caps, syrup (YES)
How Supplied:
Caps—100; Syrup—pt
