Viral infections:

Indications for: ZIAGEN ORAL SOLUTION

HIV-1 infection, in combination with other antiretroviral agents.

Adult Dosage:

300mg twice daily or 600mg once daily. Mild hepatic impairment: 200mg twice daily (use oral soln for titration).

Children Dosage:

<3mos: not established. ≥3mos (oral soln): 8mg/kg twice daily or 16mg/kg once daily; max 600mg daily. If able to swallow tabs: 14–<20kg: 300mg once daily or 150mg twice daily; ≥20–<25kg: 450mg once daily or 150mg in the AM and 300mg in the PM; ≥25kg: use Adult dose.

ZIAGEN ORAL SOLUTION Contraindications:

Presence of HLA-B*5701 allele. Prior hypersensitivity reaction to abacavir (see full labeling). Moderate or severe hepatic impairment.

Boxed Warning:

Hypersensitivity reactions.

ZIAGEN ORAL SOLUTION Warnings/Precautions:

Screen for presence of HLA-B*5701 allele prior to starting therapy or reinitiation; if (+), abacavir is contraindicated. Discontinue immediately if hypersensitivity is suspected, regardless of HLA-B*5701 status and even when other diagnoses are possible. If hypersensitivity cannot be ruled out, do not restart. If stopped for reasons other than hypersensitivity, restart only if medical care can be readily accessed. Suspend if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Possible risk of MI; minimize risk factors for coronary heart disease (eg, hypertension, hyperlipidemia, diabetes, smoking). Women. Obesity. Elderly. Pregnancy. Nursing mothers: not recommended.

See Also:

ZIAGEN ORAL SOLUTION Classification:

Nucleoside analogue (reverse transcriptase inhibitor).

ZIAGEN ORAL SOLUTION Interactions:

May antagonize methadone. May be potentiated by ethanol.

Adverse Reactions:

Nausea, vomiting, headache, malaise, fatigue, dreams/sleep disorders, diarrhea, fever, chills, rash (may be severe, eg, Stevens-Johnson), ear/nose/throat infections; hypersensitivity reactions (may be fatal), lactic acidosis, severe hepatomegaly with steatosis, immune reconstitution syndrome.

Note:

Register pregnant patients exposed to abacavir by calling (800) 258-4263. Register patients who have had a hypersensitivity reaction to abacavir by calling (800) 270-0425.

How Supplied:

Tabs—60; Soln—240mL