Asthma/COPD:
Indications for: ZYFLO
Prophylaxis and chronic treatment of asthma.
Adult Dosage:
Swallow whole. Take with meals and at bedtime. 600mg four times daily; max: 2400mg/day.
Children Dosage:
<12yrs: not recommended.
ZYFLO Contraindications:
Active liver disease. Persistent ALT elevations ≥3xULN.
ZYFLO Warnings/Precautions:
Not for primary treatment of acute attacks. Monitor liver function before initiating therapy, monthly for the 1st 3 months, every 2–3 months for the remainder of the year, and periodically thereafter (discontinue if signs/symptoms occur). History of liver disease. Alcohol consumption. Evaluate if neuropsychiatric events occur. Pregnancy (Cat.C). Nursing mothers: not recommended.
See Also:
ZYFLO Classification:
5-lipoxygenase inhibitor.
ZYFLO Interactions:
Potentiates theophylline (reduce dose of theophylline by about ½). Potentiates warfarin, propranolol (possibly other β-blockers); monitor and adjust doses. Monitor concomitant CYP3A4 inhibitors (eg, ketoconazole).
Adverse Reactions:
Sinusitis, pharyngolaryngeal pain, abdominal pain, nausea, dyspepsia, headache, rash, hypersensitivity, hepatotoxicity, upper respiratory tract infection, myalgia; neuropsychiatric events (eg, sleep disorders, behavior changes).
Generic Drug Availability:
YES
How Supplied:
Tabs, CR tabs—120
