Gout:
Indications for: ZYLOPRIM
Gout.
Adult Dosage:
Take with food. Initially 100mg daily. Maintain prophylactic therapy initially. Increase by 100mg daily increments at weekly intervals; max 800mg/day and 300mg/dose. Usual range: mild: 200–300mg daily; severe: 400–600mg daily.
Children Dosage:
Not recommended.
ZYLOPRIM Warnings/Precautions:
Discontinue at 1st sign of skin rash. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy. Nursing mothers.
ZYLOPRIM Classification:
Xanthine oxidase inhibitor.
ZYLOPRIM Interactions:
Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.
Adverse Reactions:
Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, SJS, DRESS, generalized vasculitis), renal failure.
How Supplied:
100mg—100; 300mg—100, 500
Hyperuricemia:
Indications for: ZYLOPRIM
Hyperuricosuria and hyperuricemia induced nephropathy due to cancer chemotherapy.
Adult Dosage:
600–800mg daily for 2–3 days with fluids.
Children Dosage:
Not recommended.
ZYLOPRIM Warnings/Precautions:
Discontinue at 1st sign of skin rash. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy. Nursing mothers.
ZYLOPRIM Classification:
Xanthine oxidase inhibitor.
ZYLOPRIM Interactions:
Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.
Adverse Reactions:
Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, SJS, DRESS, generalized vasculitis), renal failure.
How Supplied:
100mg—100; 300mg—100, 500
Miscellaneous urogenital disorders:
Indications for: ZYLOPRIM
Management of recurrent calcium oxalate calculi in hyperuricosurics. Hyperuricosuria and hyperuricemia induced nephropathy due to cancer chemotherapy.
Adult Dosage:
Take with food. Calculi: 200–300mg daily. Adjust based on urinary urate levels. Chemotherapy-induced nephropathy prophylaxis: 600–800mg daily for 2–3 days with fluids.
Children Dosage:
Usually not recommended. Chemotherapy–induced nephropathy prophylaxis: <6yrs: 150mg daily. 6–10yrs: 300mg daily.
ZYLOPRIM Warnings/Precautions:
Discontinue if rash occurs. Use only if daily uric acid excretion exceeds 800mg in males or 750mg in females. Advise reduction of animal protein, sodium, refined sugars, oxalate-rich foods, and excessive calcium intake. Increase fiber intake. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy (Cat.C). Nursing mothers.
ZYLOPRIM Classification:
Xanthine oxidase inhibitor.
ZYLOPRIM Interactions:
Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.
Adverse Reactions:
Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, SJS, DRESS, generalized vasculitis), renal failure.
How Supplied:
100mg—100; 300mg—100, 500
