Endometrial Cancer

Pembrolizumab: Cost-Effective for Recurrent, MSI-H Endometrial Cancer

Pembrolizumab: Cost-Effective for Recurrent, MSI-H Endometrial Cancer

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Per-cycle, PLD cost $2509, bevacizumab cost $7585, and pembrolizumab cost $9026.

Bevacizumab Plus Chemotherapy Prolongs PFS in Endometrial Cancer With p53 Null Status

Bevacizumab Plus Chemotherapy Prolongs PFS in Endometrial Cancer With p53 Null Status

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p53 mutational status may be a viable strategy upon which to base the course of therapy.

Everolimus Plus Letrozole May Be Active in Recurrent Endometrial Carcinoma

Everolimus Plus Letrozole May Be Active in Recurrent Endometrial Carcinoma

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Researchers randomly assigned 74 patients to receive everolimus plus letrozole daily or tamoxifen daily plus medroxyprogesterone daily on alternating weeks.

Endometrial Cancer: Adjuvant Taxane Plus Platinum Agent Does Not Improve Outcomes

Endometrial Cancer: Adjuvant Taxane Plus Platinum Agent Does Not Improve Outcomes

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A study concluded that adjuvant therapy with a taxane and a platinum agent was not superior over standard therapy for women with high-risk endometrial cancer.

Endometrial Cancer: Some Durable Responses to Pembrolizumab

Endometrial Cancer: Some Durable Responses to Pembrolizumab

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A subset of patients with advanced endometrial cancer experienced durable partial responses to pembrolizumab.

Sentinel Lymph Node Mapping Cost-effective in Endometrial Carcinoma

Sentinel Lymph Node Mapping Cost-effective in Endometrial Carcinoma

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Study data suggest that SLN mapping is more cost-effective and more efficacious than routine LND or selective LND.

Aggressive Endometrial Cancer Subtypes More Common in African American Population

Aggressive Endometrial Cancer Subtypes More Common in African American Population

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Study results suggest that aggressive molecular subtypes of endometrial cancer are more common among the African American population.

Isolated Tumor Cells and Routine Adjuvant Chemotherapy in Endometrial Cancer

Isolated Tumor Cells and Routine Adjuvant Chemotherapy in Endometrial Cancer

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Patients with endometrial cancer who have isolated tumor cells identified by sentinel lymph node mapping should not routinely receive adjuvant chemotherapy.

Weight Loss Decreases Risk of Endometrial Cancer

Weight Loss Decreases Risk of Endometrial Cancer

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Weight loss during menopause is associated with a lower risk of endometrial cancer.

Sentinel Lymph Node Biopsy Effective for Endometrial Cancer Staging

Sentinel Lymph Node Biopsy Effective for Endometrial Cancer Staging

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Sentinel lymph node mapping with indocyanine green accurately diagnoses metastatic disease in patients with endometrial cancer.

Hormone Therapy to Preserve Fertility May Not Affect Survival

Hormone Therapy to Preserve Fertility May Not Affect Survival

For young patients with endometrial cancer, survival does not appear to be significantly impacted by hormone therapy (HT) to preserve fertility.

Obesity-driven Endometrial Cancer Raises Need for Intervention

Obesity-driven Endometrial Cancer Raises Need for Intervention

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In women, the association between obesity and endometrial cancer is stronger than in any other type of cancer.

Use of Aromatase Inhibitors in Advanced Endometrial Cancer

Use of Aromatase Inhibitors in Advanced Endometrial Cancer

This article reviews the current evidence for the role of aromatase inhibitors (AIs) in the treatment of advanced stage or recurrent endometrial cancer.

Selinexor May Benefit Patients Ovarian or Endometrial Cancer

Selinexor May Benefit Patients Ovarian or Endometrial Cancer

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Treatment with selinexor is active in patients with heavily pretreated patients with metastatic ovarian or endometrial cancer.

Patterns in PI3K Signaling Pathway Aberrations Evaluated

Patterns in PI3K Signaling Pathway Aberrations Evaluated

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Researchers argue that combination therapies targeting both mutations in the PI3K pathway and HER2 or hormone receptor overexpression should be evaluated across cancer types.

Advanced Mismatch Repair Deficiency Tumors Respond to Pembrolizumab

Advanced Mismatch Repair Deficiency Tumors Respond to Pembrolizumab

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Patients with mismatch repair deficiency cancers may receive durable clinical benefit with pembrolizumab.

Limiting Lynch Syndrome Screening in Endometrial Cancers May Be Harmful

Limiting Lynch Syndrome Screening in Endometrial Cancers May Be Harmful

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Limiting Lynch syndrome (LS) testing to women younger than 60 years could result in missing a significant number of genetic disease.

Across Racial Groups, Endometrial Cancer Incidence on the Rise

Across Racial Groups, Endometrial Cancer Incidence on the Rise

The incidence of endometrial cancers is elevated for women across all racial/ethnic groups, while non-Hispanic black women have excess incidence.

Oral Contraceptives May Protect Against Endometrial Cancer

Oral Contraceptives May Protect Against Endometrial Cancer

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Use of oral contraceptives confers long-term protection against endometrial cancer.

ASCO Endorses ASTRO Guidelines for Radiation Therapy Following Surgery for Endometrial Cancer

ASCO Endorses ASTRO Guidelines for Radiation Therapy Following Surgery for Endometrial Cancer

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ASCO's endorsement of the ASTRO guidelines for adjuvant radiotherapy for endometrial cancer provides additional guidance for clinicians.

Robotic Surgery Viable for Obese Women with Endometrial Cancer

Robotic Surgery Viable for Obese Women with Endometrial Cancer

Robotic surgery is safe and feasible for the surgical management of morbidly obese patients with endometrial cancer.

Ridaforolimus for Endometrial Cancer Demonstrates Activity, High Toxicity

Ridaforolimus for Endometrial Cancer Demonstrates Activity, High Toxicity

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Ridaforolimus demonstrates activity in advanced endometrial cancer but is associated with significant toxicity.

Mediterranean Diet May Lower Risk of Endometrial Cancer

Mediterranean Diet May Lower Risk of Endometrial Cancer

Adhering to a Mediterranean diet may significantly reduce a woman's risk of endometrial cancer.

Dovitinib Shows Activity in Advanced Endometrial Cancer

Dovitinib Shows Activity in Advanced Endometrial Cancer

Second-line dovitinib in FGFR2-mutated and FGFR2-non-mutated advanced or metastatic endometrial cancer had single-agent activity.

Oral Bisphosphonates Reduce Endometrial Cancer Risk

Oral Bisphosphonates Reduce Endometrial Cancer Risk

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Oral bisphosphonates may greatly reduce the risk of endometrial cancer.

High Coffee Intake Linked with Lower Endometrial Cancer Risk

High Coffee Intake Linked with Lower Endometrial Cancer Risk

High versus low intake of coffee is associated with a reduced risk for endometrial cancer.

Soy, Isoflavone Intake Not Linked to Endometrial Cancer

Soy, Isoflavone Intake Not Linked to Endometrial Cancer

Soy food/isoflavone intake is not associated with endometrial cancer risk in Japanese women.

Everolimus, Letrozole Show Clinical Benefit in Recurrent Endometrial Cancer

Everolimus, Letrozole Show Clinical Benefit in Recurrent Endometrial Cancer

Patients with endometriod histology and CTNNB1 mutations responded well to everolimus and letrozole.

Certain Bisphosphonates Linked to Lower Endometrial Cancer Risk

Certain Bisphosphonates Linked to Lower Endometrial Cancer Risk

Nitrogen-containing bisphosphonates associated with reduced risk of endometrial cancer.

Radiotherapy in Pelvic Cancers Doesn't Increase Risk for Second Cancers

Radiotherapy in Pelvic Cancers Doesn't Increase Risk for Second Cancers

Compared to patients who were treated with surgery alone, radiotherapy didn't increase risk for second cancers in pelvic cancers.

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