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EOVIST
Imaging agents
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Drug Name:

EOVIST Rx

Generic Name and Formulations:
Gadoxetate disodium 181.43mg/mL (0.25mmol/mL); soln for IV inj; preservative-free.

Company:
Bayer Healthcare Pharmaceuticals Inc.

Therapeutic Use:

Indications for EOVIST:

For use in MRI of the liver to detect and characterize lesions in patients with known or suspected focal liver disease.

Adults and Children:

Premature infants: not established. Give as IV bolus inj at a rate of ~2mL/sec. 0.1mL/kg (0.025mmol/kg); flush IV cannula with normal saline after inj. See full labeling re: imaging guidelines.

Boxed Warning:

Nephrogenic systemic fibrosis.

Warnings/Precautions:

Increased risk of nephrogenic systemic fibrosis in chronic kidney disease or acute kidney injury; avoid use. Screen for renal dysfunction. Do not exceed recommended dose and allow sufficient time for drug elimination before re-administration. Have emergency resuscitative equipment available. History of asthma or other allergic disorders. Monitor for signs/symptoms of hypersensitivity reactions during and after administration. Increased risk of gadolinium retention with multiple lifetime doses, in pregnant patients, children, and those with inflammatory conditions; minimize repetitive imaging studies. Elevated bilirubin (>3mg/dL) or ferritin may reduce hepatic contrast effect; perform MRI no later than 60mins following administration. Avoid extravasation. Severe renal or hepatic failure. Elderly. Pregnancy. Nursing mothers: consider interrupting nursing and pumping/discarding breast milk for up to 10hrs after inj.

Pharmacological Class:

Gadolinium-based contrast agent.

Interactions:

Serum iron using complexometric methods may result in falsely high or low values for up to 24hrs.

Adverse Reactions:

Nausea, headache, feeling hot, dizziness, back pain; hypersensitivity reactions.

How Supplied:

Single-dose vials (10mL, 15mL)—5


Data provided by MPR.

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