Benefit of Ramucirumab in Relapsed Hepatocellular Carcinoma Confirmed in Pooled Analysis

Share this content:
Ramucirumab prolonged progression-free survival (PFS) and overall survival (OS) in patients with relapsed/refractory hepatocellular carcinoma (HCC).
Ramucirumab prolonged progression-free survival (PFS) and overall survival (OS) in patients with relapsed/refractory hepatocellular carcinoma (HCC).
The following article features coverage from the ESMO World Congress on Gastrointestinal Cancer 2018 meeting. Click here to read more of Cancer Therapy Advisor's conference coverage.

Ramucirumab prolonged progression-free survival (PFS) and overall survival (OS) in patients with relapsed/refractory hepatocellular carcinoma (HCC), according to a pooled analysis of the REACH and REACH-2 data presented at the ESMO World Congress on Gastrointestinal Cancer 2018.1

Both REACH and REACH-2 (ClinicalTrials.gov Identifier: NCT01140347 and NCT02435433, respectively) were multicenter, phase 3 studies that evaluated ramucirumab versus placebo in patients with HCC after progression during or after sorafenib. Though both trials had similar eligibility criteria, REACH-2 only included patients with baseline alpha fetoprotein (AFP) greater than or equal to 400 ng/mL. Both trials met their primary endpoints of improved OS compared with placebo. The purpose of this study was to analyze outcomes from the pooled data from both trials.

The pooled analysis included 542 patients, who had similar baseline characteristics between the ramucirumab and placebo groups, including baseline AFP levels.

Outcomes of the pooled data were similar to those observed in the individual trials. The objective response rate was 5.4% with ramucirumab and 0.9% with placebo, with a disease control rates of 56.3% and 37.2%, respectively.

OS was significantly prolonged with ramucirumab with a median of 8.1 months compared with 5.0 months with placebo (hazard ratio [HR], 0.69; 95% CI, 0.57-0.84; P = .0002). PFS was also longer with ramucirumab with a median of 2.8 months compared with 1.5 months with placebo (HR, 0.57; 95% CI, 0.47-0.69; P < .0001).

Discontinuation due to treatment-related adverse effects (TRAEs) occurred more frequently with ramucirumab at 9.5% compared with 3.6% with placebo. The most common grade 3 or higher TRAEs that occurred with ramucirumab or placebo were hypertension (12.0% vs 3.6%) and hyponatremia (5.1% vs 2.2%).

The authors concluded that the pooled analysis of the REACH and REACH-2 trials confirms the benefit of second-line ramucirumab in patients with HCC with a baseline AFP greater than or  equal to 400 ng/mL.

Read more of Cancer Therapy Advisor's coverage of the ESMO World Congress on Gastrointestinal Cancer 2018 meeting by visiting the conference page.

Reference

  1. Zhu A, Finn R, Galle P, et al. Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma (HCC) and elevated alpha-fetoprotein (AFP) following first-line sorafenib: Pooled efficacy and safety across two global randomized phase 3 studies (REACH-2 and REACH). Ann Oncol. 2018;29 (suppl 5;abstr LBA-001):v122-3. doi: 10.1093/annonc/mdy208

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs