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FLOLAN
Pulmonary hypertension
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Drug Name:

FLOLAN Rx

Generic Name and Formulations:
Epoprostenol (as sodium) 0.5mg, 1.5mg; per vial; pwd for IV infusion after reconstitution.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for FLOLAN:

Pulmonary arterial hypertension (PAH) (WHO Group I) in patients with NYHA Class III or IV symptoms, to improve exercise ability.

Adult:

Give by continuous chronic IV infusion through a central venous catheter. Initially 2ng/kg/min; increase in increments of 1–2ng/kg/min at ≥15min intervals based on response. Decrease dose gradually in 2ng/kg/min decrements at ≥15min intervals until dose-limiting effects resolve.

Children:

Not established.

Contraindications:

Heart failure due to reduced left ventricular ejection fraction.

Warnings/Precautions:

Avoid abrupt withdrawal or large dose reductions (may cause rebound pulmonary hypertension). Discontinue if pulmonary edema occurs; do not restart. Increased risk for hemorrhagic complications. Monitor BP and symptoms of vasodilation during initiation and after dose changes. Pregnancy. Nursing mothers.

Pharmacological Class:

Prostacyclin analogue.

Interactions:

Hypotensive effects may be potentiated by diuretics, antihypertensive agents, other vasodilators. Increased risk of bleeding with anticoagulants, antiplatelets.

Adverse Reactions:

Dizziness, jaw pain, headache, musculoskeletal pain, nausea, vomiting, flushing.

How Supplied:

Vials—1 (w. diluent)


Data provided by MPR.

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