Gastrointestinal Cancer

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

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Telomerase plays a crucial role in tumor proliferation, and a better understanding of its structure will pave the way for new drug development.

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

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Many clinical trials and systematic reviews note that the use of cannabinoids also comes with adverse events, including a clinical entity that has been gaining evidence in the literature over the last decade called cannabinoid hyperemesis syndrome.

Chronic Myeloid Leukemia and Gastrointestinal Cancer Risk—In the Clinic

Chronic Myeloid Leukemia and Gastrointestinal Cancer Risk—In the Clinic

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There are some clinical data to support a potential for increased risk of additional solid organ malignancies in patients with CML.

Can Oncolytic Viruses Improve Immunotherapies?

Can Oncolytic Viruses Improve Immunotherapies?

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Emerging evidence shows that injecting tumors directly into one tumor can trigger systemic antitumor immunity and immune attacks on untreated tumors elsewhere in the body.

Hepatocellular Carcinoma Treatment Regimens

Find cancer treatment regimens for hepatocellular carcinoma, including drugs such as sorafenib (Nexavar) and chemotherapy/radiotherapy clinical trials.

Patients with advanced adenomas are at increased risk of developing colorectal cancer

In this randomized screening trial, patients with advanced adenomas detected by flex sigmoidoscopy (FSG) were at significantly increased risk of CRC compared to those with no adenomas.

Clonally Transmissible Cancers in Nature

Clonally Transmissible Cancers in Nature

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While a recent discovery of a series of communicable cancers has raised concerns, there has been no sign of readily transmittable cancer in people that could spread through a population the way the ones found in other species do.

Nodal Response to Neoadjuvant Therapy Predictive of Survival in Esophageal Cancer

Nodal Response to Neoadjuvant Therapy Predictive of Survival in Esophageal Cancer

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Findings on the predictive nature of nodal response to neoadjuvant therapy from the American Association for Thoracic Surgery 98th Annual Meeting.

Esophageal and Esophagogastric Junction Cancer Treatment Regimens

Find the latest cancer treatment regimens for esophageal and esophagogastric junction cancers, including drugs such as ECF, cisplatin, and 5-FU.

The Hunt for Effective Anticancer Vaccines

The Hunt for Effective Anticancer Vaccines

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Researchers are hotly pursuing 2 distinct biological paths that show remarkable promise in the hunt for an effective anticancer vaccine.

Bursectomy Does Not Improve Survival in Gastric Cancer

Bursectomy Does Not Improve Survival in Gastric Cancer

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Researchers randomly assigned 1204 patients with gastric adenocarcinoma to undergo omentectomy only or bursectomy.

Dasatinib May Be Effective in Imatinib-Resistant Gastrointestinal Stromal Tumors

Dasatinib May Be Effective in Imatinib-Resistant Gastrointestinal Stromal Tumors

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An objective tumor response was reported in 25% of patients.

Phase 1/2 Trial of CAR-T Cell Immunotherapy in Metastatic, Mesothelin-Expressing Cancer

Phase 1/2 Trial of CAR-T Cell Immunotherapy in Metastatic, Mesothelin-Expressing Cancer

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Researchers are evaluating whether CAR-T cell immunotherapy that targets mesothelin is safe and effective among patients with mesothelin-expressing tumors.

Rectal Cancer: Adjuvant Chemotherapy May Improve OS After pCR

Rectal Cancer: Adjuvant Chemotherapy May Improve OS After pCR

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After a median follow-up of 3.1 years, patients who received adjuvant chemotherapy had improved rates of survival.

HIV-Associated Cancers: A Paradigm Shift?

HIV-Associated Cancers: A Paradigm Shift?

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Many HIV-associated cancers develop with the help of oncoviruses — some of which are sexually transmitted.

BEACON CRC Safety Lead-in Study suggests safety and efficacy of triplet combination therapy for treatment of metastatic colorectal cancer

Preliminary analysis of the Safety Lead-in Study for the BEACON CRC reveals that the triplet combination is generally well tolerated and has promising clinical activity with an overall response rate of 41%.

Gastric Cancer: Postoperative Chemoradiotherapy Does Not Improve OS vs Chemotherapy

Gastric Cancer: Postoperative Chemoradiotherapy Does Not Improve OS vs Chemotherapy

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Researchers randomly assigned 788 patients to receive postoperative chemotherapy or chemoradiotherapy.

Hot tea consumption associated with increased esophageal cancer risk in high-risk individuals

1. Hot tea consumption in combination with excessive smoking or alcohol use was associated with a higher risk for esophageal cancer. 2. In the absence of excessive alcohol use and smoking, daily tea drinking was not linked to increased risk for esophageal cancer. Evidence Rating Level: 1 (Excellent)      Study Rundown: Esophageal cancer is a concern []

iPad app that allows patients to order tests doubles colon cancer screening rates in study

The authors of this study at Wake Forest School of Medicine aimed to evaluate whether utilizing an iPad app as a digital health intervention could result in higher screening rates for CRC.

Research Suggests 6-Month Adjuvant Chemotherapy May Be Superior to 3-Months in Stage III Colon Cancer, Particularly in T4 and/or N2 Subgroups

Research Suggests 6-Month Adjuvant Chemotherapy May Be Superior to 3-Months in Stage III Colon Cancer, Particularly in T4 and/or N2 Subgroups

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Evidence from previous studies have shown that the legacy standard of 12-month fluoropyrimidine-based therapy could be reduced to 6 months, and perhaps even further to 3 months.

Tivantinib Fails to Improve Overall Survival As Second-Line Treatment in Liver Cancer

Tivantinib Fails to Improve Overall Survival As Second-Line Treatment in Liver Cancer

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Previous studies have demonstrated tivantinib prolonged progression-free survival and overall survival in hepatocellular carcinoma.

Anticancer Immunotherapy to Circumvent Tumor Resistance to Immune Checkpoint Inhibitors

Anticancer Immunotherapy to Circumvent Tumor Resistance to Immune Checkpoint Inhibitors

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Most tumors do not respond, or evolve resistance, to immune checkpoint inhibition. Now, researchers at Johns Hopkins have engineered a new class of cancer immunotherapy agents designed to short-circuit key mechanisms of tumors' disruption and evasion of immune system attack.

Colonoscopy significantly reduces mortality from colorectal cancer in Veterans Affairs study

Colorectal cancer (CRC) screening serves as a critical element of CRC prevention and management. To date, colonoscopy remains the gold standard with respect to CRC screening in the United States.

Phase 1 Trials: Therapy, Not Just Science

Phase 1 Trials: Therapy, Not Just Science

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Phase 1 trials should be considered therapeutic options for some patients.

Immunotherapy and the Risk of Myocarditis

Immunotherapy and the Risk of Myocarditis

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The risk should not discourage patients with cancer from taking these potentially life-extending therapies.

Obstructing Colorectal Cancer: Presentation and Stenting — In the Clinic

Obstructing Colorectal Cancer: Presentation and Stenting — In the Clinic

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Colonic stenting can be used as a temporizing measure to help bridge the patient to surgery for optimal timing.

Model May Identify Patients With Gastric Cancer Likely To Benefit From Chemotherapy

Model May Identify Patients With Gastric Cancer Likely To Benefit From Chemotherapy

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Researchers identified 4 classifier genes relevant to gastric cancer in 307 patients in an internal cohort.

Modified XELIRI Yields Similar Outcomes to FOLFIRI in Metastatic CRC

Modified XELIRI Yields Similar Outcomes to FOLFIRI in Metastatic CRC

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The purpose of this trial was to determine the efficacy and safety of mXELIRI as a second-line therapy for CRC in an Asian population.

Clostridium Difficile Infection in Patients With Cancer — In the Clinic

Clostridium Difficile Infection in Patients With Cancer — In the Clinic

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While CDI is becoming more common in all hospitalized patients, patients with cancer appear to be at an elevated risk.

Can A Consortium of Hospitals Help To Reduce Drug Prices?

Can A Consortium of Hospitals Help To Reduce Drug Prices?

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To help curb drug prices, a consortium of hospital groups recently announced plans to form their own nonprofit drug company.

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