Belly Fat Linked to Risk of Esophageal Cancer

This article originally appeared here.
Share this content:
Central Adiposity Linked to Risk of Esophageal Cancer
Central Adiposity Linked to Risk of Esophageal Cancer

(HealthDay News) -- A systematic review and meta-analysis of observational studies shows that central adiposity, independent of body mass index (BMI), is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma, according to research published in the November issue of Clinical Gastroenterology and Hepatology.

Siddharth Singh, M.B.B.S., of the Mayo Clinic in Rochester, Minn., and colleagues conducted a systematic review and meta-analysis to assess the association between central adiposity and erosive esophagitis (EE), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC).

The researchers found that, compared with patients with normal physique, those with central adiposity had an increased risk of EE (19 studies; adjusted odds ratio [aOR], 1.87). An association between central adiposity and increased risk of BE (17 studies; aOR, 1.98) was found, and persisted after adjustment for BMI (five studies; aOR, 1.88). In studies using gastroesophageal reflux disease (GERD) patients as controls or adjusting for GERD symptoms, a reflux-independent association between visceral fat and BE (11 studies; aOR, 2.04) was identified. Central adiposity also was linked with greater risk of EAC (six studies; aOR, 2.51).

"Future studies aimed at understanding the mechanistic effect of obesity on esophageal inflammation and neoplasia should focus on visceral fat rather than overall obesity," the authors write.

Full Text

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs