Variant rs9929218 Linked with Prognosis of Patients with CRC
the Cancer Therapy Advisor take:
Patients with stage 4 colorectal cancer (CRC) who have the variant rs9929218 at 16q22 (intron 2 of CDH1, encoding E-cadherin) are at an increased risk for worse survival and poor response to chemotherapy, according to an article published online in the journal Clinical Cancer Research.
Initially, the authors analyzed 20 single-nucleotide polymorphism (SNPs) associated with risk of CRC from 14 genome-wide loci and how they affected the prognosis of 2,083 patients with CRC.
Secondly, three SNPs were analyzed from an independent group of 5,552 patients with advanced stage CRC.
Results showed three variants in the training phase were associated with patient survival. However, only one variant (rs9929218) had a significant association in the validation phase.
Patients who were homozygous for the minor allele, especially those with stage 4 cancer (P=2.7 x 10-5), were observed to have worse survival (training phase HR, 1.43; 95% CI: 1.20, 1.71; P=5.8 × 10−5; validation phase; HR, 1.18; 95% CI: 1.01, 1.37; P=3.2 × 10−2; combined HR, 1.28; 95% CI: 1.14, 1.43; P=2.2 × 10−5).
Furthermore, a significant correlation was observed between the variant rs9929218 and a negative response to chemotherapy (P=3.9 x 10-4).
The study suggests that these findings provide a mechanism underlying rs9929218’s potential in making a patient prognosis.
Patients with colorectal cancer who have the variant rs9929218 at 16q22 are at an increased risk for worse survival.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- A Vegan Diet and Cancer
- As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination
- Bowel Preparation for Colorectal Cancer Screening: Improving Outcomes
- Tool for Assessing Frailty Predicts Survival in Newly Diagnosed Multiple Myeloma
- Analysis Supports Flat Dose of Nivolumab 480 mg Every 4 Weeks
- FDA-Approved Breast Cancer Drug Treatments
- A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy
- FDA-Approved Prostate Cancer Drug Treatments
- FDA-Approved Colorectal Cancer Drug Treatments
- Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?
- Treatment Delays May Mean Worse Survival in Head and Neck Cancer
- New Combo for Chronic Myeloid Leukemia Shows Activity In Vitro
- Age-adjusted Comorbidity Predicts Survival in Laryngeal Cancer
- Are Next-Gen Antibody-Drug Conjugates a Path Forward for Non-Hodgkin Lymphoma and Myeloma?
- Role of miR-125a-5p Clarified in Bladder Cancer