Combined Tobacco, Alcohol Use Spikes Esophageal Cancer Risk

Share this content:
Combined Tobacco, Alcohol Use Spikes Esophageal Cancer Risk
Combined Tobacco, Alcohol Use Spikes Esophageal Cancer Risk

Rates of esophageal squamous cell carcinoma (ESCC) nearly double for those who use tobacco and consume alcohol, compared to individuals who only smoke or drink. The results of this study, reported online in the American Journal of Gastroenterology, are the first to examine the interaction between tobacco and alcohol in the risk of ESCC; each has separately been established as a risk factor.

Lead author Anoop Prabhu, MD, from the University of Michigan Medical School and colleagues performed a systematic review of existing population-based case-control or cohort studies on tobacco and alcohol together as factors that increase the risk of ESCC. While using tobacco or alcohol was associated with a 20% to 30% increased risk of developing ESCC compared to those who refrain, using both was linked to a threefold risk for ESCC (summary-adjusted OR, 3.28; 95% CI 2.11, 508). The summary synergy factor for ever-use of both tobacco and alcohol was 1.85 (95% CI 1.45, 2.28)

RELATED: Gastrointestinal Cancers Resource Center

The authors note that in order to reduce rates of esophageal cancer, it is important for physicians to focus efforts on this population that uses both alcohol and tobacco.

For more information visit the American Journal of Gastroenterology website.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs