Addition of Erlotinib to Sorafenib Does Not Improve Survival in Advanced Liver Cancer
the Cancer Therapy Advisor take:
According to a new study published in the Journal of Clinical Oncology, researchers have found that the addition of erlotinib to sorafenib does not improve survival in patients with advanced hepatocellular carcinoma.
For the international, double-blind, placebo-controlled phase 3 study, researchers sought to determine whether adding erlotinib to sorafenib would improve clinical outcomes for patients with advanced hepatocellular carcinoma.
Researchers enrolled 720 patients with advanced hepatocellular carcinoma and underlying Child-Pugh class A liver cirrhosis and randomly assigned them to receive sorafenib plus either placebo or erlotinib. All patients had not received systemic treatment prior to the study.
Results showed that the median overall survivals were similar across both arms (9.5 months in the sorafenib plus erlotinib group versus 8.5 months in the sorafenib plus placebo group; HR = 0.929; P = 0.408). The median time to progression was also similar in both arms (3.2 months versus 4.0 months; HR = 1.135; P = 0.18).
The overall response rate was slightly higher in the sorafenib plus erlotinib arm (P = 0.102), but the disease control rate was significantly lower in that arm (P = 0.021). In regard to safety, adverse events were similar in both arms.
Addition of erlotinib to sorafenib does not improve survival in patients with advanced hepatocellular carcinoma.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- A Vegan Diet and Cancer
- Are Next-Gen Antibody-Drug Conjugates a Path Forward for Non-Hodgkin Lymphoma and Myeloma?
- Ponatinib Tops Bosutinib for Third-Line Treatment of CML in a Comparative Analysis
- Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer
- Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection
- FDA-Approved Breast Cancer Drug Treatments
- A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy
- FDA-Approved Prostate Cancer Drug Treatments
- FDA-Approved Colorectal Cancer Drug Treatments
- Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?
- Combination Abiraterone Acetate, Radium-223 Not Recommended in CRPC With Bone Mets
- Brigatinib Found More Effective for ALK-positive NSCLC Brain Mets Compared With Crizotinib
- Higher Baseline AFP Linked to Greater Benefit With Cabozantinib in Hepatocellular Carcinoma
- Real-World Study Shows High Response Rates to T-VEC in Early Metastatic Melanoma
- A Big BiTE: Tetravalent BiTE Highly Potent in HER2-positive Breast Cancer Models