Interval Cancer Risk Tied to Adenoma Detection Rate

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Interval Cancer Risk Tied to Adenoma Detection Rate
Interval Cancer Risk Tied to Adenoma Detection Rate

(HealthDay News) — The adenoma detection rate for screening colonoscopy performed by a physician is inversely associated with patient risk of subsequent colorectal cancer (interval cancer) and death, according to research published in the April 3 issue of the New England Journal of Medicine.

Douglas A. Corley, MD, PhD, of Kaiser Permanente in Oakland, CA, and colleagues evaluated data from 314,872 colonoscopies performed by 136 gastroenterologists and assessed the association between the colorectal adenocarcinoma detection rate and the risk of interval colorectal cancer.

RELATED: Gastrointestinal Cancers Resource Center

The researchers found that, for patients of physicians with adenoma detection rates in the highest quintile, compared with patients of physicians with detection rates in the lowest quintile, the risk of interval cancer was reduced for any interval cancer (adjusted hazard ratio [aHR], 0.52; 95% confidence interval [CI], 0.39 to 0.69), advanced-stage interval cancer (aHR, 0.43; 95% CI, 0.29 to 0.64), and fatal interval cancer (aHR, 0.38; 95% CI, 0.22 to 0.65).

For each 1% increase in the adenoma detection rate, the risk of cancer was decreased by 3% (HR, 0.97; 95% CI, 0.96 to 0.98).

"The adenoma detection rate was inversely associated with the risks of interval colorectal cancer, advanced-stage interval cancer, and fatal interval cancer," the researchers wrote.

The patients in the study were members of Kaiser Permanente Northern California, and the Kaiser Permanente Community Benefit program contributed funding to the study.


  1. Corley DA, Jensen CD, Marks AR, et al. Adenoma Detection Rate and Risk of Colorectal Cancer and Death. N Engl J Med. 2014; 370:1298-1306.

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