More Frequent Upper Endoscopies Recommended for At-Risk Gastric Cancer Population
The investigators aimed to “evaluate the association between the interval between upper gastrointestinal endoscopies and the gastric cancer stage at diagnosis in patients from a region of high prevalence.” To meet this aim, the investigators studied a cohort of 2485 patients diagnosed with gastric adenocarcinoma, stratifying them into 7 groups: 1-, 2-, 3-, 4-, 5-, >5-year intervals between upper endoscopies and those who had never been screened.
The following results were reported. The risk of higher cancer stage at diagnosis increased by 23% per increase in interval length (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.19–1.28). Compared to the never-screened group, the OR of having a higher stage of cancer decreased gradually from 0.53 (95% CI = 0.41–0.69) in the >5-year interval group to 0.31 (95% CI = 0.24–0.40) in the 1-year interval group. Compared to the 1-year interval group, the risk of advanced gastric cancer was increased in the 4- and 5-year, but not the 2- and 3-year, interval groups. However, patients with a family history of gastric cancer were more likely to have a higher stage at diagnosis if they had a 3-year interval rather than a 1-year interval.
The investigators concluded: “Endoscopy intervals of 3 years or less showed significant benefits, but family members of gastric cancer patients may benefit from intervals of under 3 years.”