Review: Inflammation's Role in Obesity-Colorectal Cancer Link

This article originally appeared here.
Share this content:
Review: Inflammation's Role in Obesity-Colorectal Cancer Link
Review: Inflammation's Role in Obesity-Colorectal Cancer Link

(HealthDay News) -- A new review summarizes the ways in which inflammation and altered metabolism are associated with colorectal cancer in obese individuals; the review was published online Sept. 3 in Obesity Reviews.

Einav Yehuda-Shnaidman, Ph.D., R.D., and Bertha Schwartz, Ph.D., from the Hebrew University of Jerusalem, reviewed the interactions between adipocytes and immune cells that may alter the metabolism towards promotion of colorectal cancer.

The researchers found that obese and lean adipose tissue had distinct immunogenic profiles, body fat distribution, and metabolic profiles. Free fatty acids, adipokines, and pro-inflammatory cytokines were released by obese adipose tissue and played a role in regulating malignant transformations and cancer progression. Two different phenotypes of macrophages were identified in adipose tissue: M1 macrophages, which were found in obese adipose tissue, produced pro-inflammatory cytokines, while M2 macrophages, which were the main type found in lean adipose tissue, produced anti-inflammatory cytokines such as interleukin-10.

"Despite establishing unequivocal epidemiological evidence of links between obesity and colorectal cancer, at least some of the mechanisms linking the two remain elusive," the authors write. "To identify these mechanisms, it is necessary to understand how obesity interacts with colorectal cancer at the molecular and cellular levels."

Abstract

Full Text (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs