Vandetanib May Not Be Effective for Advanced Biliary Tract Cancer
the Cancer Therapy Advisor take:
According to a new study published in the journal Annals of Oncology, researchers have found that vandetanib did not improve progression-free survival in patients with advanced biliary tract cancer.
For the phase 2 multi center study, researchers sought to investigate the safety and efficacy of vandetanib alone compared with vandetanib with gemcitabine or gemcitabine plus placebo in patients with advanced biliary tract cancer.
Researchers enrolled 173 patients and randomly assigned them 1:1:1 to receive either vandetanib 300mg orally daily alone, vandetanib 100mg orally daily plus gemcitabine 1,000mg/m2 IV on days 1 and 8 of each 21-day cycle, or gemcitabine 1,000mg/m2 IV on days 1 and 8 of each 21-day cycle plus placebo.
Results showed that the median progression-free survival was 105 days (95% CI: 72 - 155) for vandetanib monotherapy, 114 days (95% CI: 91 - 193) for vandetanib plus gemcitabine, and 148 days (95% CI: 71 - 225) for gemcitabine plus placebo (P = 0.18).
In addition, the vandetanib plus gemcitabine combination provided a slightly higher objective response rate over the other interventions. In regard to safety, the incidence of adverse effects was similar across all three treatment arms.
Vandetanib did not improve progression-free survival in patients with advanced biliary tract cancer.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- FDA Approves Ivosidenib for IDH1-Mutated Relapsed/Refractory Acute Myeloid Leukemia
- Clinical Stage at First Response May Predict Outcomes in Chronic Lymphocytic Leukemia
- Exercise and Cancer
- Increased Body Mass Index May Be Predictive of Recurrence, Progression in Bladder Cancer
- Aspirin, Non-Aspirin NSAID-Use May Improve Survival Outcomes in Ovarian Cancer