Vegetables, Not Fruit, Reduce Risk of Hepatocellular Carcinoma

Share this content:
Reduction in summary relative risk with increased vegetable, but not fruit, intake.
Reduction in summary relative risk with increased vegetable, but not fruit, intake.

Increased intake of vegetables, but not fruit, is associated with a reduction in the risk of hepatocellular carcinoma (HCC), according to research published in Gastroenterology.

Yang Yang, from the Zhejiang Cancer Hospital in Hangzhou, China, and colleagues performed a meta-analysis of observational studies to quantify the correlation between vegetable and fruit consumption and risk of HCC. The authors included 19 studies involving 1,290,045 participants and 3,912 cases of HCC.

The researchers found that for individuals with high versus low intake of vegetables, the summary relative risk for HCC was 0.72 (95 percent confidence interval [CI], 0.63 to 0.83). A 100 g/day daily increase in vegetable intake correlated with a summary relative risk of 0.92 for HCC (95 percent CI, 0.88 to 0.95).

RELATED: For Hepatocellular Carcinoma, Protein May Trigger Cancer Cell Death

The association persisted irrespective of history of hepatitis, alcohol drinking, smoking, or energy intake. For high versus low intake of fruit, the summary relative risk for HCC was 0.93 (95 percent CI, 0.80 to 1.09); for a 100 g/day daily increase in fruit intake, the summary relative risk was 0.99 (95 percent CI, 0.94 to 1.05).

"Based on a meta-analysis, increased intake of vegetables, but not fruit, is associated with lower risk for HCC," the authors write. "The findings should be confirmed by future studies with validated questionnaires and strict control of confounders."

Reference

  1. Yang Yang, et al. " Increased Intake of Vegetables, But Not Fruit, Reduces Risk for Hepatocellular Carcinoma: A Meta-analysis." Gastroenterology. DOI: http://dx.doi.org/10.1053/j.gastro.2014.08.005. August 12, 2014.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs