High-Dose Vitamin D 'Somewhat Favorable' in Fracture Prevention

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High-Dose Vitamin D 'Somewhat Favorable' in Fracture Prevention
High-Dose Vitamin D 'Somewhat Favorable' in Fracture Prevention

(HealthDay News) – High-dose (≥800 IU daily) vitamin D supplementation is associated with a decreased risk of hip fracture and non-vertebral fractures among older adults, according to a study published in the July 5 issue of the New England Journal of Medicine.

Heike A. Bischoff-Ferrari, MD, Dr.P.H., from the University of Zurich, and colleagues pooled participant-level data from participants (aged 65 years of age or older) from 11 double-blind, randomized, controlled trials of oral vitamin D supplementation (daily, weekly, or every 4 months), with or without calcium.

The researchers found that among 31,022 persons (mean age, 76 years; 91% women) there were 1,111 incident hip fractures and 3,770 non-vertebral fractures. Compared with control groups, participants who were randomly assigned to receive vitamin D had a non-significant decrease in the risk of hip fracture (hazard ratio [HR], 0.90; 95% confidence interval [CI], 0.80 to 1.01) and a significant decrease in the risk of non-vertebral fracture (HR, 0.93; 95% CI, 0.87 to 0.99). The reduction in the risk of fracture was seen for the highest intake quartile (median, 800 IU daily) (HR, 0.70 and 0.86 for hip fracture and non-vertebral fracture, respectively). The benefits seen at the highest level of vitamin D intake were consistent across subgroups defined by type of dwelling, age group, baseline 25-hydroxyvitamin D level, and additional intake of calcium.

"High-dose vitamin D supplementation (≥800 IU daily) was somewhat favorable in the prevention of hip fracture and any non-vertebral fracture in persons 65 years of age or older," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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