New, Combined Equation More Accurately Estimates GFR

Share this content:
New, Combined Equation More Accurately Estimates GFR
New, Combined Equation More Accurately Estimates GFR

(HealthDay News) – A combined creatinine-cystatin C equation has improved performance and accuracy for estimating glomerular filtration rate (GFR), according to research published in the July 5 issue of the New England Journal of Medicine.

Using data from 13 studies involving 5,352 participants, Lesley A. Inker, MD, from Tufts Medical Center in Boston, and colleagues developed estimating equations based on cystatin C alone and in combination with creatinine. Validation of the equations was performed in 1,119 participants from 5 different studies in which GFR had been measured.

In the validation set, the researchers found that the creatinine-cystatin C equation performed better than equations that used creatinine or cystatin C alone. Bias among the 3 equations was similar. The combined equation had significantly improved precision (interquartile range of the difference, 13.4 vs 15.4 and 16.4 ml/min/1.73 m², respectively) and accuracy (percentage of estimates that were >30% of measured GFR, 8.5 vs 12.8 and 14.1, respectively). For participants with a creatinine-based estimated GFR of 45 to 74 ml/min/1.73 m², the combined equation improved classification (net reclassification index, 19.4%) and correctly reclassified 16.9% of patients with a creatinine-based estimated GFR of 45 to 59 ml/min/1.73 m² to ≥60 ml/min/1.73 m².

"The combination of serum creatinine and serum cystatin C is more accurate than either marker alone for estimating GFR," the authors write. "The new equations represent an advance over currently available equations across the range of GFR and in relevant subgroups."

Two study authors and the editorial author disclosed financial ties to the pharmaceutical and biotechnology industries.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs