Psychological Distress Linked to Increased Mortality

Share this content:
Psychological Distress Linked to Increased Mortality
Psychological Distress Linked to Increased Mortality

(HealthDay News) -- There is a dose-response association for psychological distress and the risk of several causes of mortality, with increased mortality seen even at lower levels of distress, according to a meta-analysis published July 31 in BMJ.

To quantify the link between lower, subclinically symptomatic levels of psychological distress and cause-specific mortality, Tom C. Russ, from the Murray Royal Hospital in Perth, U.K., and colleagues conducted a meta-analysis of 10 large prospective cohort studies from the Health Survey for England involving 68,222 adults. Participants were 35 years or older and free from cardiovascular disease and cancer.

The researchers found that, after adjustment for age and sex, psychological distress correlated with an increased risk of mortality, with a dose-response association seen across the full range of distress severity (adjusted hazard ratio [aHR] for General Health Questionnaire scores of 1 to 3 versus 0, 1.20; aHR for scores 4 to 6, 1.43; aHR for scores 7 to 12, 1.94). The association persisted after further adjustment for somatic comorbidity and behavioral and socioeconomic variables. For cardiovascular disease deaths and deaths from external causes a similar association was observed. For cancer death the correlation was only seen at higher levels of psychological distress.

"Depression is a serious and debilitating disorder requiring treatment in its own right, but the finding that any level of psychological distress is associated with increased mortality and an increased risk of death from cardiovascular disease, external causes, and cancer (albeit only at higher levels of distress) is highly important," the authors write.

Full Text
Editorial (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs