Incidence Rates for Anal Carcinoma, Adenocarcinoma Have Increased Significantly
the Cancer Therapy Advisor take:
Incidence rates (IRs) of anal squamous cell carcinoma (SCC) and squamous carcinoma in situ (CIS) have significantly increased overtime, according to an article published online in the journal Cancer Epidemiology, Biomarkers & Prevention.
The authors of the study used data from the Surveillance, Epidemiology and End Results (SEER) Program to estimate age-adjusted anal cancer IRs by demographic and tumor characteristics from 2000 to 2011. Trends in annual percent changes and IRs from 1977 to 2011 were compared to those of rectal cancer.
Results showed females were associated with higher rates of SCC (rate ratio [RR]=1.45; 95% CI: 1.40, 1.50) and lower rates of ADC (RR=0.68; 95%CI: 0.62, 0.74) and squamous carcinoma in situ (CIS; RR=0.36; 95%CI: 0.34, 0.38) compared to males.
Furthermore, African Americans demonstrated lower rates of SCC (RR=0.82; 95% CI: 0.77, 0.87) and CIS (RR=0.90; 95% CI: 0.83, 0.98) but higher rates of ADC (RR=1.48; 95% CI 1.29-1.70) compared to non-Hispanic whites.
From 1992 to 2011, SCC IRs increased 2.9% per year, ADC IRs declined non-significantly, and CIS IRs increased 14.2% per year.
The authors noted similar trends were observed in SCC and ADC IRs across anal and rectal cancers.

Incidence rates of anal squamous cell carcinoma and squamous carcinoma in situ have significantly increased overtime.
Incidence rates (IRs) of anal squamous cell carcinoma (SCC) and squamous carcinoma in situ (CIS) have significantly increased overtime.
Related Resources
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
Bone Cancer | Regimens | Drugs |
Brain Cancer | Regimens | Drugs |
Breast Cancer | Regimens | Drugs |
Endocrine Cancer | Regimens | Drugs |
Gastrointestinal Cancer | Regimens | Drugs |
Gynecologic Cancer | Regimens | Drugs |
Head and Neck Cancer | Regimens | Drugs |
Hematologic Cancer | Regimens | Drugs |
Lung Cancer | Regimens | Drugs |
Other Cancers | Regimens | |
Prostate Cancer | Regimens | Drugs |
Rare Cancers | Regimens | |
Renal Cell Carcinoma | Regimens | Drugs |
Skin Cancer | Regimens | Drugs |
Urologic Cancers | Regimens | Drugs |
Cancer Therapy Advisor Articles
- Clinical Applications of Liquid Biopsies in Cancer
- Two-Drug Combination Superior to Sunitinib in Patients With Untreated Advanced Renal Cell Carcinoma
- Immunotherapy in Glioblastoma: Peaks and Pits
- Investigational Antiandrogen Drug Delays Metastasis in CRPC
- Opinion: Understanding the FDA's Take on Cannabidiol
- OS and PFS End Points Not Met in Phase 3 Trial of Pembrolizumab in Advanced HCC
- No Benefit Observed With Osimertinib Plus Durvalumab in EGFR-Mutated NSCLC
- Evidence of the Role of Circulating Insulin in Renal Cell Carcinoma Risk
- Treatment Guidelines in Cancer: Assessing Industry Influence on Recommendations
- American Society of Breast Surgeons Recommends Genetic Testing for All Patients With Breast Cancer