B Vitamin, Omega-3 Supplementation for Cancer Prevention: No Benefit for Patients with Prior Cardiovascular Disease

Share this content:

(ChemotherapyAdvisor) – No association was noted between cancer outcomes and B vitamins and/or omega-3 fatty acids following five years of dietary supplementation; however, omega-3 fatty acids appear to increase cancer risk in women with prior cardiovascular disease, an ancillary study of a secondary prevention trial published in Archives of Internal Medicine online February 13 has found.

Between 2003 and 2009, the Supplementation with Folate, Vitamins B6 and B12 and/or Omega-3 Fatty Acids (SU.FOL.OM3) study in France randomized 2,501 individuals ages 45 to 80 years with a prior myocardial infarction, unstable angina, or ischemic stroke during the previous year to one of four daily supplementation groups: 5-methyltetrahydrofolate (0.56mg), pyridoxine hydrochloride (vitamin B6; 3mg) and cyanocobalamin (vitamin B12; 0.02mg); eicosapentaenoic and docosahexaenoic acid (600mg) in a 2:1 ratio; B vitamins and omega-3 fatty acids; or placebo.

After five years, 145 incident cancer events occurred in 1,987 men and 29 in 514 women, 83% of whom were menopausal. While there was no effect of treatment on cancer risk among men, women had three times the risk when taking omega-3 fatty acids (HR=3.02). Cancer events occurred in 7.0% of patients and death from cancer in 2.3%.

The authors caution that the results were “derived from very few cases and should be regarded as preliminary."

Abstract

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs