No Link Between Prenatal Exposure to Cancer, Early Childhood Development

Share this content:
Prenatal exposure to maternal cancer, with or without treatment, had no effect on cognitive, cardiac, or general development of children.
Prenatal exposure to maternal cancer, with or without treatment, had no effect on cognitive, cardiac, or general development of children.

Prenatal exposure to maternal cancer, with or without treatment, had no effect on cognitive, cardiac, or general development of children in early childhood, according to an article published online in The New England Journal of Medicine.1

Long-term outcome data on children who were exposed to prenatal maternal cancer are lacking. Investigators conducted a multicenter case-control study where children whose mothers were diagnosed with cancer during pregnancy were compared with children of mothers who were not.

A total of 129 children (median age 22 months; range 12 to 42) were included in the prenatal-exposure group, with a matching number in the control group. During pregnancy, 96 children (74.4%) were exposed to chemotherapy, 11 children (8.5%) were exposed to radiotherapy, 13 children (10.9%) were exposed to surgery alone, and 2 children (1.6%) to other drug treatments.

Results showed that the birth weight was below the 10th percentile in 28 of 127 children (22.0%) in the prenatal-exposure group and in 19 of 125 children (15.2%) in the control group (P=0.16).

RELATED: Cancers Identified with Maternal Plasma Cell-Free DNA Sequencing

Cognitive development on the basis of the Bayley score did not differ between the groups (P=0.08). Cognitive outcome for both groups was correlated with gestational age at birth.

There were normal cardiac findings among 47 children who were evaluated at 36 months. Prematurity was linked to a worse outcome, independent of prenatal exposure to cancer.

Reference

  1. Amant F, Vandenbroucke T, Verheecke M, et al. Pediatric outcome after maternal cancer diagnosed during pregnancy. [published online ahead of print September 28, 2015]. N Engl J Med. doi: 10.1056/NEJMoa1508913.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs