New Compound Sensitizes Cancer Cells to Chemotherapy

Share this content:

the Cancer Therapy Advisor take:

According to new results published in the journal Angewandte Chemie - International Edition, researchers from three German institutions have identified a novel class of chemical compounds that sensitize cancer cells to chemotherapeutic drugs.


Furthermore, they identified the target enzyme of these chemicals, thus opening the possibility of developing new drugs that target that enzyme. The compound from the class of chemicals the researchers identified stimulates the death of rapidly proliferating cells by chemotherapeutic drugs. The compound is non-toxic. By sensitizing cancer cells to chemotherapy, lower doses of chemotherapy can be used, which will in turn decrease toxicity and resistance.


The new class of compounds is called T8, which specifically sensitizes cancer cells to the drug etoposide. Protein disulfide isomerase (PDI) is the target protein that the researchers identified for novel agents to have a sensitizing effect. In addition, the researchers found that the effect on PDI is reversible and its effect is only observed when administered with a chemotherapeutic agent like etoposide.


The researchers also say that T8 is capable of sensitizing various types of cancer cells, including breast, leukemic, and pancreatic cancer cells. The researchers hope to test T8 in a variety of in-vivo animal models and determine whether PDI can be used as a drug target.

Early studies show that continual low-dose chemotherapy lessens toxicity.
A novel class of chemical compounds that sensitize cancer cells to chemotherapeutic drugs.

Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich report that a new class of chemical compounds makes cancer cells more sensitive to chemotherapeutic drugs. They have also pinpointed the relevant target enzyme, thus identifying a new target for anti-tumor agents. Researchers led by LMU's Professor Angelika Vollmar and Professor Stephan Sieber of the Technische Universität München have identified a class of chemicals that represent a potential new weapon in the fight against malignant tumors.

The compound is itself non-toxic, but it stimulates the killing of rapidly dividing cells by chemotherapeutic drugs. This sensitizing effect means that the latter can be used in lower doses, which makes it less likely that the target cells will become resistant to their lethal effect. The work was carried out by an interdisciplinary collaboration made up of scientists from LMU, TUM and the Saarland University in Saarbrücken, and the results appear in the latest issue of the journal "Angewandte Chemie - International Edition".

READ FULL ARTICLE From Medical News Today

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs