Young Patients with Non-Germinal B-cell-Like Lymphoma Benefit from Dose-Intensive R-ACVBP vs. R-CHOP

the Cancer Therapy Advisor take:

According to new findings published in the Journal of Clinical Oncology, researchers have found that the Hans algorithm may be useful as a theragnostic biomarker for identifying young patients with non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL) who may benefit from dose-intensive rituximab, doxorubicin, cyclophophamide, vindesine, bleomycin, and prednisone (R-ACVBP) rather than being treated with standard rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisone (R-CHOP).

For the analysis of data from the phase 3 trial LNH 03-2B, researchers sought to identify whether any biomarkers could predict which patients with DLBCL would experience a survival advantage when treated with dose-intensive R-ACVBP compared with R-CHOP. Researchers analyzed the interaction effects between various biomarkers and each treatment arm of the LNH 03-2B study on survival.

They used the Hans algorithm to classify tumors as GCB or non-GCB. They found that only the interaction between the Hans algorithm and the treatment arm was significantly associated with progression-free survival and overall survival (P = 0.01).

Progression-free survival and overall survival were similar between both regimens among patients with GCB tumors, but patients with non-GCB tumors had better outcomes when treated with dose-intensive R-ACVBP compared with R-CHOP.