In Stage 3 NSCLC, Cisplatin Plus Etoposide vs. Carboplatin Plus Paclitaxel Show Similar Survival
the Cancer Therapy Advisor take:
According to a new study published in the Journal of Clinical Oncology, etoposide plus cisplatin results in a similar overall survival as carboplatin plus paclitaxel for the treatment of stage 3 non-small cell lung cancer (NSCLC) in a Veterans Health Administration population, but etoposide plus cisplatin was associated with increased morbidity.
For the study, researchers identified 1,842 patients with stage 3 NSCLC who were treated with either etoposide-cisplatin or carboplatin-paclitaxel with concurrent radiation between 2001 and 2010.
Various analyses demonstrated that treatment with etoposide-cisplatin did not result in a longer duration of overall survival compared with treatment with carboplatin-paclitaxel. A Cox proportional hazards model found a hazard ratio of 0.97 (95% CI: 0.85 - 1.10), a propensity score matched cohort determined a hazard ratio of 1.07 (95% CI: 0.91 - 1.24), and a propensity score adjusted model found a hazard ratio of 0.97 (95% CI: 0.85 - 1.10).
In addition, patients treated with etoposide-cisplatin had more hospitalizations (P < 0.001), outpatient visits (P < 0.001), infections (P = 0.0022, kidney injury (P < 0.001), and mucositis/espophagitis (P = 0.0246).
Etoposide plus cisplatin results in a similar overall survival as carboplatin plus paclitaxel for NSCLC.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Clostridium Difficile Infection in Patients With Cancer — In the Clinic
- Can A Consortium of Hospitals Help To Reduce Drug Prices?
- NSCLC: Stratifying Patients With Complex EGFR Mutations
- Targeted and Immunotherapies for Metastatic Renal Cell Carcinoma
- Atezolizumab, Carboplatin, Nab-Paclitaxel Combination Prolongs PFS in NSCLC
- Everolimus Plus Letrozole: An Effective First-Line Therapy for Advanced Breast Cancer
- FDA Approves Nilotinib for Pediatric Patients With CML
- Nicotinamide and Cancer
- Nivolumab Plus Ipilimumab Improves Overall Survival, ORR in Renal Cell Carcinoma
- Encorafenib, Binimetinib May Be Effective in BRAF-Mutant Melanoma