Large Retroperitoneal Lymph Node Associated with VTE in Disseminated Germ Cell Tumors

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Large retroperitoneal lymph node (RPLN) is associated with venous thromboembolism (VTE) in patients with disseminated germ cell tumors (GCTs), providing better accuracy than high-risk Khorana score in this group, according to a recent study published in the Journal of Clinical Oncology.

Amirrtha Srikanthan, MD, of the Princess Margaret Cancer Centre in Toronto and fellow researchers looked at a training cohort of 216 patients with disseminated GCT who were receiving first-line chemotherapy from January 2000 to December 2010, with large RPLN defined as more than 5 centimeters in diameter.

Comparing predictive models using large RPLN with high-risk Khorana score in order to determine risk of VTE, the researchers found that the former method showed higher discriminatory accuracy, with further validation in a London cohort.

Twenty-one patients developed VTE during chemotherapy, and it was associated with large RPLN, high-risk Khorana score, intermediate- to poor-risk disease, and hospitalization.

“Prophylactic anticoagulation may be considered in high-risk patients,” the authors concluded. “Results should be validated in larger, prospective studies.”

Gene expression signature analysis of HR+ breast tumors may predict survival.
RPLN is associated with VTE in patients with disseminated germ cell tumors.
The researchers hypothesized that there was an association between large RPLN and chemotherapy-associated VTE risk. Large RPLN is associated with VTE in patients with disseminated GCT and provides higher discriminatory accuracy than high-risk Khorana score.
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