New Optical Imaging Could Improve Surgical Outcomes Following Cancer Resection
the Cancer Therapy Advisor take:
New optical imaging technology that is currently under development could “light up” cancer cells, allowing surgeons to remove more cancerous tissue than previously possible during procedures.
Development of the technology was spearheaded by Phillip Low, BS, the Ralph C. Corley Distinguished Professor of Chemistry at Purdue University and the cofounder of On Target Laboratories.
Through the use of an optical imaging molecule known as OTL38, Low and fellow Purdue researchers are hoping to prove the safety and efficacy of the compound in patients with cancer. OTL38 achieved first-in-humans status at the Center for Human Drug Research at Leiden University.
“On Target Laboratories has developed small-molecules ligands, such as OTL38, that specifically target receptors overexpressed on solid tumors,” Dr. Low said. “We have attached them to proprietary fluorescent imaging agents that allow the cancers to light up during surgery. Surgery is pivotal for the treatment of solid tumors, and our developing technology could, in the future, be the guiding light for surgeons by enabling intra-operative visualization of most such tumors.”
He believes that further collaboration with surgeons at Leiden University will allow for better testing of the novel technology in different types of cancers.
“The image guided surgery program is a prime example of how novel molecules like OTL38 ideally should be developed,” said Adam Cohen, PharmD, CEO of the Center for Human Drug Research. “
New optical imaging technology that is currently under development could “light up” cancer cells.
The technology was developed by Philip Low, the Ralph C. Corley Distinguished Professor of Chemistry at Purdue University, director of the Purdue University Center for Drug Discovery and co-founder of On Target Laboratories.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Are Next-Gen Antibody-Drug Conjugates a Path Forward for Non-Hodgkin Lymphoma and Myeloma?
- Ponatinib Tops Bosutinib for Third-Line Treatment of CML in a Comparative Analysis
- Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection
- Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer
- Treatment Delays May Mean Worse Survival in Head and Neck Cancer
- FDA-Approved Breast Cancer Drug Treatments
- A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy
- FDA-Approved Colorectal Cancer Drug Treatments
- Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?
- Emetogenic Potential of Antineoplastic Agents
- Combination Abiraterone Acetate, Radium-223 Not Recommended in CRPC With Bone Mets
- Brigatinib Found More Effective for ALK-positive NSCLC Brain Mets Compared With Crizotinib
- Higher Baseline AFP Linked to Greater Benefit With Cabozantinib in Hepatocellular Carcinoma
- Real-World Study Shows High Response Rates to T-VEC in Early Metastatic Melanoma
- A Big BiTE: Tetravalent BiTE Highly Potent in HER2-positive Breast Cancer Models